Genetics and Molecular Biology Branch

Ring chromosome - Mouse embryos - T-cells bound to an anti-CD3-coated microbead

Genetics and Molecular Biology Branch (GMBB) investigators use state-of-the-art genetic and genomic technologies to study the genomes of humans and other organisms and disease mechanisms. Their goal is to demonstrate that research findings and opportunities derived from genetic and genomic technologies may be translated into improved diagnosis, treatments and prevention of human diseases. Using the excellent resources of NHGRI intramural laboratories, the NIH Clinical Center and intramural collaborations across NIH, the branch is engaged in basic, translational and clinical research, bringing the latest genomic and genetic technologies to the study of human disease.

GMBB investigators develop and quickly evaluate novel translational approaches and advanced technologies. In addition, collaborations with the NIH Clinical Center, the NIH Intramural Sequencing Center and the NIH Chemical Genomics Center support projects that expand the breadth of single-investigator laboratories. The NHGRI core facilities are equally important components of all GMBB research efforts, giving GMBB investigators access to state-of-the-art bioinformatic, transgenic-animal, flow-cytometry, genomic and cytogenetic technologies.  These resources have allowed GMBB investigators to develop clinical trials for gene therapy of immune deficiency and preclinical development of gene therapy for metabolic disorders. In addition, GMBB investigators have discovered disease genes and identified small molecules to treat inherited diseases and malignancies.

Mentorship and preparation of trainees for their future careers is a priority for the branch. GMBB faculty provide a broad-based learning experience for trainees that is extended and integrated with the NHGRI and NIH intramural training and seminar programs.  GMBB investigators participate in outreach activities and learning opportunities, provide summer internships and mentor students from underrepresented groups.