Translational and Functional Genomics Branch

DNA methylation profiles in Uterine Corpus Endometrial Carcinoma samples - Clutch of zebrafish embryos - Image of circulating blood

By exploring the genetic, epigenetic and metagenomic basis of human disorders, investigators in the Translational and Functional Genomics Branch (TFGB) study how genome structure and function contribute to health. TFGB researchers have developed a wide range of experimental and computational techniques to study all aspects of the genomes of humans, microorganisms that live on humans and animal models of genetic disease.

TFGB investigators catalyze technology development in genetics and computational genomics, including functional assessment, systematic mutagenesis, developmental genomics and computational analysis of both human and microbial DNA.  By testing approaches and technologies in cell lines and animal models, TFGB investigators are making fundamental discoveries that will be critical to the success of human clinical trials. The long-term goal of their efforts is to successfully translate laboratory findings into improved diagnoses and therapeutics for human disorders.